From the actual situation of major pollutants emissions, there are obvious gaps in regional pollution abatement and emission reduction effect during the“11th Fiveyear” in Henan Province, and the regional differences problems of environmental pollution is increasingly becoming a big obstacle to harmonious society construction and the industrialization development of Henan Province. Therefore, this paper selected three indicators of range, the weighted coefficient of variation and Theil entropy, analyzed regional differences of major pollutants from 2006 to 2009 in Henan Province, which would provide some scientific suggestions for government to make pollution abatement measures and allocate the task of reducing emission.